COPG Polyclonal Antibody, PE-Cy7 Conjugated
Product Specifications
Background
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity) .
Synonyms
Gamma-2-COP; Gamma-2-coat protein; Coatomer subunit gamma-2; Gamma-1-COP; Gamma-1-coat protein; Coatomer subunit gamma-1.
Gene ID
22820, 26958
Cellular Locus
Cytoplasm
Host
Rabbit
Immunogen
65-165/871
Target
COPG 1/2
Clonality
Polyclonal
Isotype
IgG
Conjugation
PE-Cy7
Source
KLH conjugated synthetic peptide derived from human COPG1
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
488nm/780nm
Concentration
1µg/µl
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
22820, 26958
Predicted Cross Reactivity
Human, Mouse, Rat, Cow, Sheep, Horse
Curated Selection
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