Phospho-CHEK1 (Ser286) Polyclonal Antibody, Biotin Conjugated
Product Specifications
Background
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2011].
Synonyms
Chk1 (phospho S286) ; p-Chk1 (phospho S286) ; Chk1 (Phospho-Ser286) ; CHEK1 (phospho Ser286) ; CHEK1 (phospho Ser286) ; p-CHEK1 (Ser286) ; Cell cycle checkpoint kinase; Checkpoint, S. pombe, homolog of, 1; Checkpoint kinase 1; Checkpoint kinase 1 homolog (S. pombe) ; CHEK 1; CHEK-1; CHEK1; Chk 1; Chk1; CHK1 checkpoint homolog (S. pombe) ; EC 2.7.11.1; rad27; Serine/threonine protein kinase Chk1; Serine/threonine-protein kinase CHK1; STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) ; C85740; CHK1_HUMAN.
Gene ID
1111
Swiss Prot
O14757
Modification Site
Ser286
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Mouse
Target
Phospho-CHEK1 (Ser286)
Clonality
Polyclonal
Isotype
IgG
Conjugation
Biotin
Source
KLH conjugated Synthesised phosphopeptide derived from human CHEK1 around the phosphorylation site of Ser286.
Applications
WB, ELISA, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
1111
Predicted Cross Reactivity
Human, Dog, Pig, Horse, Chicken
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
