Methyl methanesulfonate

Methyl methanesulfonate is an alkylating agent which transfers methyl groups, and induces DNA damage. Methyl methanesulfonate is a biochemical reagent that can be used as a biological material or organic compound for life science related research[1][2].

Product Specifications

CAS Number

[66-27-3]

UNSPSC

12352200

Hazard Statement

H301, H315, H319, H334, H340, H351, H361, H373, H411

Target

DNA Alkylator/Crosslinker; MDM-2/p53; Necroptosis; Reactive Oxygen Species (ROS)

Type

Biochemical Assay Reagents

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/methyl-methanesulfonate.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

COS(C)(=O)=O

Molecular Formula

C2H6O3S

Molecular Weight

110.13

Precautions

H301, H315, H319, H334, H340, H351, H361, H373, H411

References & Citations

[1]Jiang Y, et al., Methyl methanesulfonate induces necroptosis in human lung adenoma A549 cells through the PIG-3-reactive oxygen species pathway. Tumour Biol. 2016 Mar;37 (3) :3785-95.|[2]Hosseinzadeh H, et al., Protective effect of Crocus sativus stigma extract and crocin (trans-crocin 4) on methyl methanesulfonate-induced DNA damage in mice organs. DNA Cell Biol. 2008 Dec;27 (12) :657-64.