1,6,7-Trihydroxyxanthone

1,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16[1].

Product Specifications

CAS Number

[25577-04-2]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; BMI1

Type

Natural Products

Related Pathways

Apoptosis; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-6-7-trihydroxyxanthone.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(OC3=C1C=C(O)C(O)=C3)C=CC=C2O

Molecular Formula

C13H8O5

Molecular Weight

244.20

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Fu WM, et al. MiR-218-targeting-Bmi-1 mediates the suppressive effect of 1,6,7-trihydroxyxanthone on liver cancer cells. Apoptosis. 2015 Jan;20 (1) :75-82.