1,6,7-Trihydroxyxanthone
1,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16[1].
Product Specifications
CAS Number
[25577-04-2]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; BMI1
Type
Natural Products
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1-6-7-trihydroxyxanthone.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(OC3=C1C=C(O)C(O)=C3)C=CC=C2O
Molecular Formula
C13H8O5
Molecular Weight
244.20
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Fu WM, et al. MiR-218-targeting-Bmi-1 mediates the suppressive effect of 1,6,7-trihydroxyxanthone on liver cancer cells. Apoptosis. 2015 Jan;20 (1) :75-82.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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