GRB7 Polyclonal Antibody, RBITC Conjugated

Many growth factors function by binding receptors with intrinsic tyrosine kinase activity (1,2) . Signaling by such receptors involves a series of intermediates characterized by SH2 domains that bind tyrosine phosphorylated receptors by a direct interaction between the SH2 domain and the phosphotyrosine-containing receptor sequences (3,4) . GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP and a proline-rich N-terminus (5,6) . GRB7 maps to the region on mouse chromosome 11 containing the Neu gene (6) . This region of mouse chromosome 11 is syntenic to an area of human chromosome 17q that is frequently amplified in breast cancer (6,7) . Moreover, GRB7 is amplified and over-expressed in breast cancer and is found in a complex with Neu gp185 (6) .

B47; Epidermal growth factor receptor GRB 7; Epidermal growth factor receptor GRB-7; GRB7 adapter protein; GRB7; GRB7_HUMAN; Growth factor receptor bound protein 7; Growth factor receptor-bound protein 7; OTTHUMP00000164349; OTTHUMP00000164350; OTTHUMP00000164351; OTTHUMP00000164352.