GRB 14 Polyclonal Antibody, PerCP Conjugated

Product Specifications

Background

Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR) . Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Synonyms

Growth factor receptor-bound protein 14; GRB14 adapter protein; GRB14

Gene ID

2888

Swiss Prot

Q14449

Cellular Locus

Cytoplasm, Cell membrane

Host

Rabbit

Cross Reactivity

Human

Immunogen

221-320/540

Target

GRB 14

Clonality

Polyclonal

Isotype

IgG

Conjugation

PerCP

Source

KLH conjugated synthetic peptide derived from human GRB 14

Applications

IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

482nm/677nm

Concentration

1µg/µl

Dilution

IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Specificity

This antibody may also detect the similar protein GRB10 due to an 83% sequence similarity in the immunogen sequence.

Gene ID URL

2888

Predicted Cross Reactivity

Mouse, Rat, Dog, Cow, Sheep, Horse, Chicken, Rabbit

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

550438 200 µL

Tryptophanyl tRNA Synthetase 2, Mitochondrial

Ask

View Details

LY410087 100 µg

PDZD4 (NM_032512) Human Over-expression Lysate

Ask

View Details

MBS9317587-01 48 Well

Human Dysferlin-interacting protein 1, DYSFIP1 ELISA Kit

Ask

View Details

MBS9317587-02 96 Well

Human Dysferlin-interacting protein 1, DYSFIP1 ELISA Kit

Ask

View Details

MBS9317587-03 5x 96 Well

Human Dysferlin-interacting protein 1, DYSFIP1 ELISA Kit

Ask

View Details

MBS9317587-04 10x 96 Well

Human Dysferlin-interacting protein 1, DYSFIP1 ELISA Kit

Ask

View Details