GRB 14 Polyclonal Antibody, AbBy Fluor™ 488 Conjugated

Product Specifications

Background

Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR) . Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Synonyms

Growth factor receptor-bound protein 14; GRB14 adapter protein; GRB14

Gene ID

2888

Swiss Prot

Q14449

Cellular Locus

Cytoplasm, Cell membrane

Host

Rabbit

Cross Reactivity

Human

Immunogen

221-320/540

Target

GRB 14

Clonality

Polyclonal

Isotype

IgG

Conjugation

AbBy Fluor™ 488

Source

KLH conjugated synthetic peptide derived from human GRB 14

Applications

IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

499nm/519nm

Concentration

1µg/µl

Dilution

IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Specificity

This antibody may also detect the similar protein GRB10 due to an 83% sequence similarity in the immunogen sequence.

Gene ID URL

2888

Predicted Cross Reactivity

Mouse, Rat, Dog, Cow, Sheep, Horse, Chicken, Rabbit

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

349964-01 100 µg

GSTT2, Recombinant, Human, aa1-244, His-Tag (Glutathione S-transferase theta 2)

Ask

View Details

349964-02 500 µg

GSTT2, Recombinant, Human, aa1-244, His-Tag (Glutathione S-transferase theta 2)

Ask

View Details

MBS7146064 Inquire

Rabbit anti-Saccharomyces cerevisiae (strain 204508/S288c)(Baker's yeast) FOL1 Polyclonal Antibody

Ask

View Details

RC221032L4V 200 µL

DEFB108B (NM_001002035) Human Tagged ORF Clone Lentiviral Particle

Ask

View Details

TR312964 1 Kit

FLRT3 Human shRNA Plasmid Kit (Locus ID 23767)

Ask

View Details

NBP1-76529MFV450 0.1 mL

Rabbit Polyclonal LRRTM3 Antibody [mFluor Violet 450 SE]

Ask

View Details