Phospho-Rb (Ser780) Polyclonal Antibody

Product Specifications

Background

Nuclear Marker.The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Synonyms

RbSer780; OSRC; P105 RB; P105RB; PP105; PP110; pRb; RB 1; RB1; RB1 protein; Retinoblastoma 1 including osteosarcoma; Retinoblastoma 1; Retinoblastoma associated protein; Including osteosarcoma; Osteosarcoma; p105-Rb; Rb; RB_HUMAN; Retinoblastoma suspectibility protein; Retinoblastoma-associated protein; Retinoblastoma related osteosarcoma; Retinoblastoma susceptibility gene.

Gene ID

5925

Modification Site

Ser780

Cellular Locus

Nucleus

Host

Rabbit

Cross Reactivity

Human, Mouse, Rat

Target

Phospho-Rb (Ser780)

Clonality

Polyclonal

Isotype

IgG

Conjugation

Unconjugated

Source

KLH conjugated synthetic phosphopeptide derived from human Rb around the phosphorylation site of (Ser780)

Applications

WB, ELISA, FCM, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Concentration

1µg/µl

Dilution

WB (1:300-5000), ELISA (1:500-1000), FCM (1:20-100), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)