Gemin 4 Polyclonal Antibody, Cy5 Conjugated
Product Specifications
Background
Gemin4 is a component of the SMN core complex which, while in the cytoplasm, plays an essential role in ribonucleoprotein (snRNP) assembly, including the biogenesis, delivery and recycling of snRNPs to the spliceosome. In the nucleus, where SMN is required for pre-mRNA splicing, Gemin4 concentrates next to coiled bodies in subnuclear structures called gems, that are highly enriched in splicosomal snRNPs, and in the nucleolus. Deletion or loss-of-function mutations in the SMN lead to the neurodegenerative disease spinal muscular atrophy (SMA) . The human Gemin4 maps to chromosome 17p13.
Synonyms
Gemin4; Gemin-4; Component of gems 4; Gem associated protein 4; HC56; HHRF 1; GEMI4_HUMAN.
Gene ID
50628
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Human
Immunogen
251-350/1058
Target
Gemin 4
Clonality
Polyclonal
Isotype
IgG
Conjugation
Cy5
Source
KLH conjugated synthetic peptide derived from human Gemin 4
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
625,650nm/670nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
50628
Predicted Cross Reactivity
Mouse, Rat, Dog, Rabbit
Curated Selection
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