GABA A receptor pi Polyclonal Antibody, APC Conjugated

Product Specifications

Background

GAD-65 and GAD-67, glutamate decarboxylases function to catalyze the production of GABA (Gamma-aminobutyric acid) . In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct.

Synonyms

GABAA receptor; GABAA receptor subunit pi; GABRP; Gamma aminobutyric acid GABA A receptor pi; Gamma aminobutyric acid A receptor pi; Gamma aminobutyric acid receptor pi subunit; Gamma aminobutyric acid receptor subunit pi; Gamma-aminobutyric acid receptor subunit pi; GBRP_HUMAN; MGC126386; MGC126387.

Gene ID

2568

Cellular Locus

Cell membrane

Host

Rabbit

Cross Reactivity

Mouse

Immunogen

81-180/440

Target

GABA A receptor pi

Clonality

Polyclonal

Isotype

IgG

Conjugation

APC

Source

KLH conjugated synthetic peptide derived from human GABRP/GABA A receptor pi

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

650nm/660nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

2568

Predicted Cross Reactivity

Human, Rat, Cow, Sheep, Pig, Horse, Rabbit

Curated Selection

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