Lixivaptan
Lixivaptan (VPA-985, WAY-VPA 985) is an orally active and selective vasopressin receptor V2 antagonist, with IC50 values of 1.2 and 2.3 nM for human and rat V2, respectively.
Product Specifications
CAS Number
168079-32-1
Product Name Alternative
VPA-985; WAY-VPA 985
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Vasopressin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Lixivaptan.html
Purity
99.67
Solubility
DMSO : ≥ 150 mg/mL
Smiles
O=C(C1=C(Cl)C=C(NC(C2=CC(F)=CC=C2C)=O)C=C1)N(C3)C4=CC=CC=C4CN5C3=CC=C5
Molecular Formula
C27H21ClFN3O2
Molecular Weight
473.93
Precautions
H302, H315, H319, H335
References & Citations
[1]Albright JD, et al. 5-Fluoro-2-methyl-N-[4- (5H-pyrrolo[2,1-c]-[1, 4]benzodiazepin-10 (11H) -ylcarbonyl) -3-chlorophenyl]benzamide (VPA-985) : an orally active arginine vasopressin antagonist with selectivity for V2 receptors. J Med Chem. 1998 Jul 2;41 (14) :2442-4.|[2]Ghali JK, et al. Lixivaptan, a non-peptide vasopressin V2 receptor antagonist for the potential oral treatment of hyponatremia. IDrugs. 2010 Nov;13 (11) :782-92.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
V2 Receptor
Available Sizes
Frequently Asked Questions
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