FZR1 Polyclonal Antibody
Product Specifications
Background
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Synonyms
FZR; FZR2; CDC20C; Fizzy-related protein homolog; CDC20-like protein 1; Cdh1/Hct1 homolog; FZR1; FYR; KIAA1242
Gene ID
51343
Swiss Prot
Q9UM11
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
141-240/496
Target
FZR1
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human FZR1/CDC20C
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
51343
Predicted Cross Reactivity
Dog, Cow, Sheep, Pig, Horse, Chicken
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![4,6-Dichloroimidazo[4,5-c]pyridine](https://cdn.genprice.uk/products/572/6526160441836/imageurl/trc-d434825-500mg.webp)
BNC881757-500 1x 500 µL
CELA3B / ELA3B (Pancreatic Function Marker) (CELA3B/1757), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC741104-100 1x 100 µL
PAX2 (Renal Cell & Ovarian Carcinoma Marker) (PAX2/1104), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details ![Phospho-SQSTM1 / p62 (S349) Recombinant Rabbit Monoclonal Antibody [PSH08-97]](https://cdn.genprice.uk/products/992/68dd1c8c061270361ea81cd8/imageurl/ha723050.webp)
HA723050 100 µL
Phospho-SQSTM1 / p62 (S349) Recombinant Rabbit Monoclonal Antibody [PSH08-97]
Sign In for Pricing
View Details