FUBP1 Polyclonal Antibody, AbBy Fluor™ 750 Conjugated
Product Specifications
Background
FUBP1 Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. FUBP2 Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE) . May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
Synonyms
Far upstream element-binding protein 1; FUBP1; FBP; FUSE-binding protein 1; DNA helicase V; hDH V; Far upstream element-binding protein 2; KHSRP; FUSE-binding protein 2; KH type-splicing regulatory protein; KSRP; p75; FBP2; FUBP2
Gene ID
8880
Swiss Prot
Q96AE4
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Mouse
Immunogen
551-644/644
Target
FUBP1
Clonality
Polyclonal
Isotype
IgG
Conjugation
AbBy Fluor™ 750
Source
KLH conjugated synthetic peptide derived from human FUBP1
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
749nm/775nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Specificity
This antibody detects both FUBP1 and FUBP2 (KHSRP)
Gene ID URL
8880
Predicted Cross Reactivity
Human, Rat, Dog, Cow, Sheep, Pig, Horse, Rabbit, Zebrafish
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
