Phospho-FMRP (Ser500) Polyclonal Antibody, PE-Cy5 Conjugated
Product Specifications
Background
Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity) . RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly (G), binds moderately to poly (U) but shows very little binding to poly (A) or poly (C) .
Synonyms
POF; FMRP; POF1; FRAXA; Fragile X mental retardation protein 1; Protein FMR-1; FMR1
Gene ID
2332
Swiss Prot
Q06787
Modification Site
Ser500
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
Phospho-FMRP (Ser500)
Clonality
Polyclonal
Isotype
IgG
Conjugation
PE-Cy5
Source
KLH conjugated synthetic phosphopeptide derived from human FMRP around the phosphorylation site of Ser500
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
488nm/670nm
Concentration
1µg/µl
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
2332
Predicted Cross Reactivity
Dog, Cow, Sheep, Pig, Chicken, Rabbit, Guinea Pig, Zebrafish
Curated Selection
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