FIP1L1 Polyclonal Antibody, AbBy Fluor™ 555 Conjugated
Product Specifications
Background
The Component of the Cleavage and Polyadenylation Specificity Factor (CPSF) complex plays an important role in the 3'-end formation of pre-mRNA. This complex recognizes the AAUAAA signal sequence and interacts with poly (A) polymerase to process and add to the poly (A) tail. FIP1L1 (FIP1-like 1), also known as Pre-mRNA 3'-end-processing factor FIP1, FIP1 (Factor interacting with PAP) and RHE (Rearranged in hypereosinophilia), is a 594 amino acid nuclear protein that is a component of the CPSF complex. Within the complex, FIP1L1 contributes to the poly (A) recognition and stimulates poly (A) addition. Fusion of the genes encoding FIP1L1 and PDGFRA due to an interstitial deletion on chromosome 4q12 is the cause of hypereosinophilia syndrome, a rare blood disorder characterized by continuous overproduction of eosinophils in the bone marrow that leads to tissue infiltration and organ damage. There are three isoforms of FIP1L1 that are produced as a result of alternative splicing events.
Synonyms
DKFZp586K0717; Factor interacting with PAP; FIP1; FIP1 like 1 S cerevisiae; FIP1 like 1; FLJ33619; hFip 1; hFip1; Pre mRNA 3 end processing factor FIP1; Rearranged in hypereosinophilia; RHE; FIP1_HUMAN.
Gene ID
81608
Cellular Locus
Nucleus
Host
Rabbit
Immunogen
501-594/594
Target
FIP1L1
Clonality
Polyclonal
Isotype
IgG
Conjugation
AbBy Fluor™ 555
Source
KLH conjugated synthetic peptide derived from human FIP1L1
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
553nm/568nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
81608
Predicted Cross Reactivity
Human, Mouse, Rat, Dog, Cow, Sheep, Pig, Horse, Chicken, Rabbit
Curated Selection
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