EYA4 Polyclonal Antibody, AbBy Fluor™ 488 Conjugated

A gene of chromosome 6q23 encodes the 640 amino acid protein, EYA4 (eyes absent) (1) . EYA is one of four members of the eyes absent family (1) . A 271 amino acid domain at the carboxyl terminal is highly conserved amongst the members of the eyes absent family (1) . EYA4 is expressed in the craniofacial mesenchyme, the dermamyotome, and the limb (1) . The conserved region in other EYA proteins interacts with SIX, DACH, and G-proteins, which regulate transcription in early embryonic development (1,2,3,4) . SIX translocates EYA1-3 to the nucleus, and G-proteins can stop this interaction (3,4) . Premature stop codon mutations in EYA4 cause postlingual, progressive autosomal dominant hearing loss in humans (2) . This shows that EYA4 is also vital to the mature organ of Corti (2) . EYA4 may cause oculo-dento-digital syndrome, based on its expression pattern and map postion (1) .

CMD1J; Deafness, autosomal dominant 10; DFNA 10; DFNA10; dJ78N10.1 eyes absent Drosophila homolog 4; dJ78N10.1 eyes absent; EYA 4; eya4; EYA4_HUMAN; Eyes absent 4; Eyes absent homolog 4 Drosophila; Eyes absent homolog 4; HGNC:3522; OTTHUMP00000040267.