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PROTAC_ERRα

Product Specifications

UNSPSC Description

PROTAC_ERRα is a potent and selective ERRα PROTAC degrader (DC50: 100 nM in MCF-7 cells). PROTAC_ERRα induces proteasomal degradation and has capable of specifically degrading ERRα protein by >80%. Blue: VHL ligand (HY-125845), Pink: ERRα ligand (HY-U00425), black: linker[1].

Target Antigen

Epigenetic Reader Domain; PROTACs

Type

Reference compound

Related Pathways

Epigenetics;PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-errα.html

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(/C(SC1=O)=C/C2=CC(OC)=C(C=C2)OC3=C(C=C(C=C3)C#N)C(F)(F)F)N1CCOCCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(NCC5=CC=C(C6=C(N=CS6)C)C=C5)=O)=O)=O

Molecular Weight

949.03

References & Citations

[1]Bondeson DP, et al. Catalytic in vivo protein knockdown by small-molecule PROTACs. Nat Chem Biol. 2015 Aug;11(8):611-7.

Shipping Conditions

Room Temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-147174/PROTAC-ERRα-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-147174/PROTAC-ERRα-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

1801547-15-8

Available Sizes

Curated Selection

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