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Phospho-PDGFRA (Tyr720) Polyclonal Antibody, Biotin Conjugated

Product Specifications

Background

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]

Synonyms

PDGF Receptor alpha (phospho Y720) ; p-PDGF Receptor alpha (phospho Y720) ; Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a; CD140a antigen; MGC74795; PDGF alpha chain; PDGF-R-alpha; PDGFR 2; PDGFR alpha; PDGFR2; PDGFRA; PDGFRA/BCR fusion; PGFRA_HUMAN; Platelet derived growth factor receptor 2; Platelet derived growth factor receptor alpha; Platelet derived growth factor receptor alpha polypeptide; Platelet derived growth factor receptor; Rearranged in hypereosinophilia platelet derived growth factor receptor alpha fusion protein; RHEPDGFRA.

Gene ID

5156

Swiss Prot

P16234

Modification Site

Tyr720

Cellular Locus

Cell membrane

Host

Rabbit

Cross Reactivity

Human

Target

Phospho-PDGFRA (Tyr720)

Clonality

Polyclonal

Isotype

IgG

Conjugation

Biotin

Source

KLH conjugated synthesised phosphopeptide derived from human PDGFRA around the phosphorylation site of Tyr720

Applications

WB, ELISA

Purification

Purified by Protein A.

Concentration

1µg/µl

Dilution

WB (1:300-5000), ELISA (1:500-1000)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C for 12 months.

Gene ID URL

5156

Predicted Cross Reactivity

Mouse, Rat, Cow, Sheep, Pig, Horse, Chicken, Rabbit

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