Monophosphoryl lipid A

Monophosphoryl lipid A (Glucopyranosyl lipid A) is a toll-like receptor 4 agonist. Monophosphoryl lipid A is derived from the cell wall of nonpathogenic Salmonella. Monophosphoryl lipid A can be used for the research of immunization and vaccine[1].

Product Specifications

CAS Number

[1246298-63-4]

Product Name Alternative

Glucopyranosyl lipid A

UNSPSC

12352005

Hazard Statement

H335, H371, H373

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/monophosphoryl-lipid-a.html

Purity

99.31

Smiles

CCCCCCCCCCCCCC(O[C@@H](CC(N[C@@H]1[C@@H](OC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)[C@H](OP(O)([O-])=O)[C@@H](CO)O[C@H]1OC[C@@H]2[C@@H](O)[C@H](OC(C[C@H](O)CCCCCCCCCCC)=O)[C@@H](NC(C[C@H](O)CCCCCCCCCCC)=O)[C@@H](O)O2)=O)CCCCCCCCCCC)=O.[NH4+]

Molecular Formula

C96H184N3O22P

Molecular Weight

1763.47

Precautions

H335, H371, H373

References & Citations

[1]Cheng R, et al. Recombination Monophosphoryl Lipid A-Derived Vacosome for the Development of Preventive Cancer Vaccines. ACS Appl Mater Interfaces. 2020;12 (40) :44554-44562.|[2]Ismaili J, et al. Monophosphoryl lipid A activates both human dendritic cells and T cells. J Immunol. 2002;168 (2) :926-932.