PF-04859989 (hydrochloride)
Product Specifications
Product Name Alternative
UR-8880
UNSPSC Description
PF-04859989 hydrochloride is a brain-penetrant, irreversible kynurenine aminotransferase (KAT) II inhibitor with IC50s of 23 and 263 nM for hKAT II and rKAT II. PF-04859989 hydrochloride is selective for KAT II over human KAT I, KAT III, and KAT IV (IC50s of 22, 11, and >50 μM, respectively)[1].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pf-04859989-hydrochloride.html
Purity
99.90
Solubility
DMSO : 20.83 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 100 mg/mL (ultrasonic)
Smiles
O=C1N(O)C2=C(C=CC=C2)C[C@@H]1N.[H]Cl
Molecular Weight
214.65
References & Citations
[1]Dounay AB, et al. Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia. ACS Med Chem Lett. 2012;3(3):187-192. Published 2012 Jan 25.|[2]Linderholm KR, et al. Inhibition of kynurenine aminotransferase II reduces activity of midbrain dopamine neurons. Neuropharmacology. 2016;102:42-47.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-116451/PF-04859989-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-116451/PF-04859989-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
177943-33-8
Available Sizes
Curated Selection
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