PF-04859989 (hydrochloride)
PF-04859989 hydrochloride is a brain-penetrant, irreversible kynurenine aminotransferase (KAT) II inhibitor with IC50s of 23 and 263 nM for hKAT II and rKAT II. PF-04859989 hydrochloride is selective for KAT II over human KAT I, KAT III, and KAT IV (IC50s of 22, 11, and >50 μM, respectively) [1].
Product Specifications
CAS Number
[177943-33-8]
Product Name Alternative
UR-8880
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Aminotransferases (Transaminases)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pf-04859989-hydrochloride.html
Purity
99.90
Solubility
DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C1N(O)C2=C(C=CC=C2)C[C@@H]1N.[H]Cl
Molecular Formula
C9H11ClN2O2
Molecular Weight
214.65
Precautions
H315, H319, H320
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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