4-O-Methyl honokiol

4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis, acts as a PPARγ agonist, and inhibtis NF-κB activity, used for cancer and inflammation research.

Product Specifications

CAS Number

[68592-15-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NF-κB; PPAR

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/4-O-Methyl_honokiol.html

Purity

98.18

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(CC=C)C=C1C2=CC(CC=C)=C(OC)C=C2

Molecular Formula

C19H20O2

Molecular Weight

280.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee NJ, et al. 4-O-methylhonokiol, a PPARγ agonist, inhibits prostate tumour growth: p21-mediated suppression of NF-κB activity. Br J Pharmacol. 2013 Mar;168 (5) :1133-45.|[2]Lee YJ, et al. Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models. J Neuroinflammation. 2012 Feb 19;9:35.