MAML1 Polyclonal Antibody

Notch receptors are involved in cell-fate determination in organisms as diverse as flies, frogs, and humans (1) . The 'mastermind' gene has been identified in multiple genetic screens for modifiers of Notch mutations in Drosophila melanogaster (2) . In Drosophila, loss-of-function mutations of Notch produce a 'neurogenic' phenotype in which cells destined to become epidermis switch fate and differentiate to neural cells (2) . The human homolog, mastermind-like 1 (Mam1), localizes to nuclear bodies (2-4) . Mam1 binds to the ankyrin repeat domain of all four mammalian Notch receptors, forms a DNA-binding complex with ICN and RBP-Jk, and amplifies Notch-induced transcription of Hes1 (2) . Mam1 is an essential component of the transcriptional apparatus of Notch signaling (5) . The gene which encodes Mam1 maps to human chromosome 5 (4) .