DYRK2 Polyclonal Antibody, RBITC Conjugated

Dyrk is the homolog of the Drosophila mnb (minibrain) gene, which is required for neurogenesis (13) . Dyrk is a dual-specificity tyrosine kinase and serine/threonine kinase, which is itself regulated by tyrosine phosphorylation (1) . Several mammalian Dyrk related proteins have been identified and are thought to compose a family of dual specificity protein kinases (4) . Dyrk family members, including Dyrk1A (originally Dyrk), Dyrk1B, Dryk1C, Dyrk2, Dyrk3, Dyrk4A and Dyrk4B, are thought to be involved in diverse cellular functions (4) . Dyrk1A is a candidate gene that may be involved in Downs syndrome, and it has been found to be somewhat overexpressed in Downs syndrome (1,5) . Two isoforms of human fetal brain Dyrk2 exist: a deduced 528-amino acid protein and a protein containing 73 additional amino acids at the amino terminus (4) . Dyrk3 is strongly expressed in testis, only after the onset of spermatogenesis, and very weakly expressed in spleen and adrenal gland (1) . The genes which encode Dyrk2 and Dyrk3 map to human chromosomes 12 and 1q32, respectively (4) .

1810038L18Rik; Dual specicity tyrosine Y phosphorylation regulated kinase 2; Dual specicity tyrosine phosphorylation regulated kinase 2; Dual specicity tyrosine-phosphorylation-regulated kinase 2; DYRK2; DYRK2_HUMAN; EC 2.7.12.1; FLJ21217; FLJ21365.