Muscone

Muscone is a macrocyclic ketone found naturally in a glandular secretion of the musk deer which acts at human odorant receptor OR5AN1 and is used in perfumes(1). It suppresses inflammatory responses and neuronal damage in various models including a rat model of cervical spondylotic myelopathy (2) and relieves inflammatory pain acting via the NOX4/JAK2-STAT3 and NLRP3 inflammasome pathway (3). In the cardiovascular system it alleviates myocardial ischemia-reperfusion injury (4) and improves cardiac function in mice after myocardial infarction (5) via enhancement of angiogenesis (6).

1. Ahmed L., et al. (2018) Proc. Acad. Natl. Sci. USA. 115:E3950 2. Zhou L.Y., et al. (2020) J. Neurochem. 155:154 3. Yu S., et al. (2020) Int. Immunopharmacol. 82:106355 4. Wei C.J., et al. (2021) J. Biol. Regul. Homeost. Agents. 35:85 5. Du Y., et al. (2018) Am. J. Transl. Res. 10:4235 6. Du Y., et al. (2018) Med. Sci. Monit. 24:8870