Muscone
Antiinflammatory and Neuroprotective activity
Product Specifications
Background
Muscone is a macrocyclic ketone found naturally in a glandular secretion of the musk deer which acts at human odorant receptor OR5AN1 and is used in perfumes(1). It suppresses inflammatory responses and neuronal damage in various models including a rat model of cervical spondylotic myelopathy (2) and relieves inflammatory pain acting via the NOX4/JAK2-STAT3 and NLRP3 inflammasome pathway (3). In the cardiovascular system it alleviates myocardial ischemia-reperfusion injury (4) and improves cardiac function in mice after myocardial infarction (5) via enhancement of angiogenesis (6).
CAS Number
541-91-3
Product Name Alternative
3-Methyl-cyclopentadecanone (racemic)
UNSPSC
41116105
Type
Blocker
Source
Synthetic
Field of Research
Cardiovascular System | Angiogenesis
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.005
Format
Colorless oil
Solubility
May be dissolved in DMSO (35 mg/ml); or Ethanol (35 mg/ml)
Molecular Formula
C16H30O
Molecular Weight
238.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Ahmed L., et al. (2018) Proc. Acad. Natl. Sci. USA. 115:E3950
2. Zhou L.Y., et al. (2020) J. Neurochem. 155:154
3. Yu S., et al. (2020) Int. Immunopharmacol. 82:106355
4. Wei C.J., et al. (2021) J. Biol. Regul. Homeost. Agents. 35:85
5. Du Y., et al. (2018) Am. J. Transl. Res. 10:4235
6. Du Y., et al. (2018) Med. Sci. Monit. 24:8870
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