Phospho-TIE2 (Tyr1108) Polyclonal Antibody
Product Specifications
Background
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis.TEK is closely related to the TIE receptor tyrosine kinase.
Synonyms
P-TIE2 phospho Y1108; Angiopoietin-1 receptor; CD202b; CD202b antigen; Endothelial tyrosine kinase; Endothelium specic receptor tyrosine kinase 2; hTIE 2; hTIE2; hTIE2; Hyk; p140 TEK; p140 TEK; Tek; tek tyrosine kinase; TEK tyrosine kinase endothelial; tek tyrosine kinase, endothelial; TIE 2; TIE2_HUMAN; Tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains 2; Tyrosine protein kinase receptor TEK; Tyrosine protein kinase receptor TIE 2; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2; Venous malformations multiple cutaneous and mucosal; VMCM 1; VMCM; VMCM1.
Gene ID
7010
Modification Site
Tyr1108
Cellular Locus
Cytoplasm, Secreted, Cell membrane, Extracellular matrix
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
Phospho-TIE2 (Tyr1108)
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic phosphopeptide derived from human TIE2 around the phosphorylation site of Tyr1108
Applications
WB, ELISA, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
7010
Predicted Cross Reactivity
Dog, Cow, Sheep, Pig, Horse, Chicken, Rabbit
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS163680-01 48 Well
Human V-Set Domain Containing T-Cell Activation Inhibitor 1 (VTCN1) ELISA Kit
Ask
View Details MBS163680-02 96 Well
Human V-Set Domain Containing T-Cell Activation Inhibitor 1 (VTCN1) ELISA Kit
Ask
View Details 
MBS163680-03 5x 96 Well
Human V-Set Domain Containing T-Cell Activation Inhibitor 1 (VTCN1) ELISA Kit
Ask
View Details MBS163680-04 10x 96 Well
Human V-Set Domain Containing T-Cell Activation Inhibitor 1 (VTCN1) ELISA Kit
Ask
View Details 
249499-ML405 100 µL
NRP1 (neuropilin 1, BDCA4, CD304, DKFZp686A03134, DKFZp781F1414, NP1, NRP, VEGF165R) (MaxLight 405) discontinued
Ask
View Details