A20FMDV2
A20FMDV2 is a selective αvβ6 integrin inhibitor (IC50: 3 nM), with an activity 1,000-fold more selective for αvβ6 than for other RGD-directed integrins (αvβ3, αvβ5, and α5β1) . A20FMDV2 can be derived from foot-and-mouth disease virus and is a 20-amino-acid peptide. A20FMDV2 can be radiolabeled for the PET imaging of αvβ6 integrin-positive tumors[1][2].
Product Specifications
CAS Number
932699-03-1
UNSPSC
12352209
Target
Integrin
Type
Peptides
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/a20fmdv2.html
Purity
98.03
Solubility
H2O : ≥ 100 mg/mL
Smiles
O=C(N[C@@H](C)C(N[C@@H](C(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(N)=O)N
Molecular Formula
C93H163N31O28
Molecular Weight
2163.48
References & Citations
[1]Hausner SH, et al. Use of a peptide derived from foot-and-mouth disease virus for the noninvasive imaging of human cancer: generation and evaluation of 4-[18F]fluorobenzoyl A20FMDV2 for in vivo imaging of integrin alphavbeta6 expression with positron emission tomography. Cancer Res. 2007 Aug 15;67 (16) :7833-40. |[2]Siow A, et al. Chemical Modifications on the αvβ6 Integrin Targeting A20FMDV2 Peptide: A Review. ChemMedChem. 2024 Sep 16;19 (18) :e202400131.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
A60-110D2 0.5 mg
Goal anli-Guinea pig IgG Heavy and Lighl Chain Antibody Dylighl®488 Conjugaled
Sign In for Pricing
View Details 
039884-ML650 100 µL
PES1, CT (PES1, Pescadillo homolog) (MaxLight 650) discontinued
Sign In for Pricing
View Details 244459-ML750 100 µL
CDC34 (Cell Division Cycle 34 Homolog (S. cerevisiae), E2-CDC34, UBC3, UBE2R1) (MaxLight 750) discontinued
Sign In for Pricing
View Details bs-9249R-BF647 100 µL
RNF123 Polyclonal Antibody, AbBy Fluor™ 647 Conjugated
Sign In for Pricing
View Details