D-688
D-688 is an inhibitor of Tau and Aβ. D-688 can reverse Aβ1–42-induced toxicity in SH-SH5Y cells and has significant neuroprotective properties. D-688 can improve the survival rate of Drosophila melanogaster expressing the human tau protein isoform (2N4R) [1].
Product Specifications
CAS Number
[2276762-07-1]
UNSPSC
12352005
Target
Amyloid-β; Tau Protein
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/d-688.html
Smiles
OC1=CC=C(C=C1O)C2=CC=C(C=C2)N3CCN(CC3)CCNCC4=CC=C(C=C4)F
Molecular Formula
C25H28FN3O2
Molecular Weight
421.51
References & Citations
[1]Armstrong, et al. "Novel Piperazine Based Compounds Target Alzheimer’s Disease Relevant Amyloid β42 and Tau Derived Peptide AcPHF6, and the Lead Molecule Increases Viability in the Flies Expressing Human Tau Protein." ACS Chemical Neuroscience (2024) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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