Phospho-KCNJ1 (Ser44) Polyclonal Antibody
Product Specifications
Background
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Synonyms
KCNJ1 phospho S44; p-KCNJ1 phospho S44; KCNJ1 phospho Ser44; p-KCNJ1 Ser44; p-ROM-Kphospho S44; KCNJ1 phospho S25; p-KCNJ1 phospho S25; KCNJ1 phospho Ser25; p-KCNJ1 Ser25; p-ROM-Kphospho S25; ROM K; ROM-K; inwardly rectying subfamily J member 1; ATP regulated potassium channel ROM K; ATP sensitive inward rectier potassium channel 1; ATP-regulated potassium channel ROM-K; ATP-sensitive inward rectier potassium channel 1; Inward rectier K+ channel Kir1.1; inwardly rectying K+ channel; IRK1_HUMAN; KCNJ 1; KCNJ; Kcnj1; Kir 1.1; Kir1.1; Potassium channel; Potassium channel inwardly rectying subfamily J member 1; potassium inwardly-rectying channel J1; ROMK 1; ROMK 2; ROMK; ROMK1; ROMK2.
Modification Site
Ser44
Cellular Locus
Cell membrane
Host
Rabbit
Target
Phospho-KCNJ1 (Ser44)
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic phosphopeptide derived from human KCNJ1 around the phosphorylation site of Ser44
Applications
ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Predicted Cross Reactivity
Human, Mouse, Rat, Dog, Sheep, Horse
Curated Selection
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