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Rilpivirine (hydrochloride) (Standard)

Rilpivirine (hydrochloride) (Standard) is the analytical standard of Rilpivirine (hydrochloride) . This product is intended for research and analytical applications. Rilpivirine (R278474) hydrochloride is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI) . Rilpivirine hydrochloride has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM) . Rilpivirine hydrochloride has a high genetic barrier to resistance development of HIV[1][2].

Product Specifications

CAS Number

700361-47-3

Product Name Alternative

TMC-278 (hydrochloride) (Standard) ; TMC278 (hydrochloride) (Standard) ; TMC 278 (hydrochloride) (Standard)

UNSPSC

12352005

Target

MMP; Reference Standards; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Others

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/rilpivirine-hydrochloride-standard.html

Smiles

N#CC1=CC=C(NC2=NC=CC(NC3=C(C)C=C(/C=C/C#N)C=C3C)=N2)C=C1.Cl

Molecular Formula

C22H19ClN6

Molecular Weight

402.88

References & Citations

[1]Shiori Haga, et al. TACE Antagonists Blocking ACE2 Shedding Caused by the Spike Protein of SARS-CoV Are Candidate Antiviral Compounds. Antiviral Res. 2010 Mar;85 (3) :551-5.|[2]Kruse MN, et al. Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors. Biochem J. 2004 Mar 1;378 (Pt 2) :383-9.|[3]Wang R, et al. A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling. Stem Cells Transl Med. 2016 Mar;5 (3) :331-8.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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