GABRG1 Polyclonal Antibody
Product Specifications
Background
GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid) . In the central nervous system, GABA functions as the main inhibitory transmitter by increasing a Cl- (chloride) conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors, as well as a third class of receptors called GABAC. The Gamma subunit of GABAA receptors are important for benzodiazepine binding and modulation of GABA-mediated Cl- current. GABAA R Gamma 1 (gamma-aminobutyric acid (GABA) A receptor, gamma 1), also known as GABRG1, is a 465 amino acid multi-pass membrane protein belonging to the ligand-gated ionic channel (TC 1.A.9) family. GABAA R gamma 1 participates in neurotransmission inhibition and has been linked to alcohol dependence.
Synonyms
GABAA receptor subunit gamma 1; GabaA/BZ; GABRG 1; GABRG1; Gamma aminobutyric acid GABA A receptor subunit gamma 1; Gamma aminobutyric acid A receptor, gamma 1; GBRG1
Gene ID
2565
Swiss Prot
Q8N1C3
Cellular Locus
Cell membrane
Host
Rabbit
Immunogen
65-160/465
Target
GABRG1
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human GABRG1/GABA A Receptor gamma 1
Applications
ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
2565
Predicted Cross Reactivity
Human, Mouse, Rat, Dog, Cow, Sheep, Pig, Horse, Rabbit
Curated Selection
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