Phospho-GARB1 (Ser434) Polyclonal Antibody, AbBy Fluor™ 350 Conjugated
Selected Variant
bs-12064R-BF350
Size: 100 µL
Product Specifications
Background
GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (g-aminobutyric acid) . In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA R alpha 1-6, GABAA R beta 1-3, GABAA R©1-3, GABAA R∂ , GABAA R gamma, GABAA R delta 1 and GABAA R delta 2. The GABAB family is composed of GABAB R1 alpha and GABAB R1 beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2 and -3) . The GABA transporters function to terminate GABA action.
Synonyms
GABA A Receptor beta 1 phospho S434; GARB1 Ser 434; GABAA receptor subunit beta-1; GABA-A receptor, beta-1 polypeptide; Gabrb-1; Gamma Aminobutyric Acid A Receptor Beta 1; Gamma Aminobutyric Acid Receptor , beta-1; Gamma-aminobutyric acid GABA A receptor, subunit beta 1; Gamma-aminobutyric acid receptor subunit beta-1; GARB1; GABRA1; AW061132; B230208N19Rik; GABAA receptor beta 1; GABAA receptor subunit beta-1; GABA-A receptor, beta-1 polypeptide; Gabrb-1; GABRB1; Gamma aminobutyric acid GABA A receptor beta 1; Gamma Aminobutyric Acid A Receptor Beta 1; Gamma Aminobutyric Acid Receptor , beta-1; Gamma-aminobutyric acid GABA A receptor, subunit beta 1; Gamma-aminobutyric acid receptor subunit beta-1; GARB1; GBRB1_HUMAN.
Modification Site
Ser434
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Mouse
Target
Phospho-GARB1 (Ser434)
Clonality
Polyclonal
Isotype
IgG
Conjugation
AbBy Fluor™ 350
Source
KLH conjugated synthetic phosphopeptide derived from human GARB1 around the phosphorylation site of Ser434
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
346nm/442nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Predicted Cross Reactivity
Human, Rat, Cow, Sheep, Pig, Horse, Rabbit
Price
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