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Cyclin Y Polyclonal Antibody, PE Conjugated

Product Specifications

Background

Cyclin Y is a 341 amino acid protein belonging to the cyclin family. Cyclin Y exists as three alternatively spliced isoforms and contains a cyclin N-terminal domain. Cyclin Y may control cell division cycles and regulate cyclin-dependent kinases.Cell proliferation is controlled at specific stages of the cell cycle by distinct protein kinase complexes. These complexes consist of a catalytic subunit associating with a specific regulatory subunit to form the active kinase. The cyclins, which include cyclin A, B, C, D, E, F, G, H, I, K, L, T, Y and their related proteins, including Dbf4, comprise the regulatory subunits of these kinase complexes. The controlled activation of the kinase complexes at various intervals of the cell cycle is regulated by the availability of the cyclins to the catalytic subunit. Unlike the catalytic subunit, which is expressed continually, the expression and stability of the regulatory subunit fluctuates depending on the stage of the cell cycle, thereby regulating kinase activity.

Synonyms

C10orf9; CBCP1; CCNX; CCNY; CFP1; Chromosome 10 open reading frame 9; Cyclin box carrying protein 1; Cyclin box protein 1; Cyclin fold protein 1; Cyclin X; Cyclin Y; CCNY_HUMAN.

Gene ID

219771

Cellular Locus

Cytoplasm, Nucleus, Cell membrane

Host

Rabbit

Immunogen

21-120/341

Target

Cyclin Y

Clonality

Polyclonal

Isotype

IgG

Conjugation

PE

Source

KLH conjugated synthetic peptide derived from human Cyclin Y/Cyclin X

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

496,564nm/578nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

219771

Predicted Cross Reactivity

Human, Mouse, Rat, Dog, Cow, Sheep, Pig, Chicken, Rabbit

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