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ADRA2C Polyclonal Antibody, FITC Conjugated

Product Specifications

Background

Alpha2C-adrenergic receptors (alpha2C-AR) regulate neurotransmitter release from sympathetic nerves in the heart, and from adrenergic neurons in the central nervous system. alpha2C-AR can influence Parkinson?s disease, panic disorders, and Huntington disease (HD) progression. A genetic variant in the alpha2C-AR coding region (Del322-325) renders the receptor partially uncoupled from Gi, and is a contributing risk factor for heart failure. alpha2C-AR transcripts are present in rat muscle, heart, pancreas, and kidney.

Synonyms

Adra 2c; Adra 2c; ADRA2C; ADRA2C; ADRA2L2; ADRA2L2; ADRA2RL2; ADRA2RL2; ADRARL2; ADRARL2; Adrenergic alpha 2C receptor; Adrenoceptor alpha 2C; Alpha 2C adrenergic receptor; Alpha 2C adrenergic receptor subtype C4; Alpha 2C adrenoceptor; Alpha 2C adrenoreceptor; Alpha 2CAR; alpha2 AR C4; alpha2 AR C4; alpha2 C4; alpha2 C4; alpha2C; alpha2C; ALPHA2CAR; alpha2cii-adrenergic receptor; Subtype alpha2 C4; Subtype alpha2 C4; ADA2C_HUMAN.

Cellular Locus

Cell membrane

Host

Rabbit

Cross Reactivity

Human

Immunogen

21-120/462

Target

ADRA2C

Clonality

Polyclonal

Isotype

IgG

Conjugation

FITC

Source

KLH conjugated synthetic peptide derived from human ADRA2C/alpha 2C Adrenergic Receptor

Applications

FCM, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

494nm/518nm

Concentration

1µg/µl

Dilution

FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Predicted Cross Reactivity

Mouse, Rat, Dog, Pig

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