HLA-DR Polyclonal Antibody
Product Specifications
Background
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]
Synonyms
MLRW; HLA-DRA1; HLA class II histocompatibility antigen, DR alpha chain; MHC class II antigen DRA; HLA-DRA
Gene ID
3122
Swiss Prot
P01903
Cellular Locus
Extracellular
Host
Rabbit
Cross Reactivity
Human
Immunogen
30-80/254
Target
HLA-DR
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human HLA-DRA
Applications
WB, IHC-P, IHC-F, IF
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:1000-5000), IHC-P (1:1000-5000), IHC-F (1:1000-5000), IF (1:500-2000)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Product Datasheet
https://www.biossantibodies.com/datasheets/bs-1198R
Gene ID URL
3122
Curated Selection
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