Neurabin 1 Polyclonal Antibody, HRP Conjugated

Brain-specific neurabin I (neural tissue-specific F-actin binding protein I) is highly concentrated in the synapse of developed neurons; it localizes in the growth cone lamellipodia during neuronal development (1) . Suppression of endogenous neurabin in rat hippocampal neurons inhibits neurite formation (1) . Neurabin I recruits active PP1 via a PP1-docking sequence; mutation of the PP1-binding motif halts filopodia and restores stress fibers in neurabin I-expressing cells (2,3) . Neurabin II (Spinophilin) is ubiquitously expressed but is abundantly expressed in brain (4) . Neurabin II localizes to neuronal dentritic spines, which are the specialized protrusions from dendritic shafts that receive most of the excitatory input in the CNS (5) . Neurabin II may regulate dendritic spine properties as neurabin II (-) mice have increased spine density during development in vitro and exhibit altered filopodial formation in cultured cells (5) . Neurabin may also play a role in glutamatergic transmission as Neurabin II (-) mice exhibit reduced long-term depression and resistance to kainate-induced seizures and neronal apoptosis (5) . Neurabin II complexes with the catalytic subunit of protein phosphatase-1 (PP1) in vitro thus modulating the activity of PP1 (4) .

FLJ20068; KIAA1222; NEB1_HUMAN; Neurabin I; Neurabin-1; Neurabin-I; Neurabin1; Neurabin-1; NeurabinI; Neurabin1; Neural tissue specic F actin binding protein I; Neural tissue-specic F-actin-binding protein I; NRB 1; NRB I; NRB1; NRBI; PPP1R9A; Protein phosphatase 1 regulatory inhibitor subunit 9A; Protein phosphatase 1 regulatory subunit 9A.