CACNA2 Polyclonal Antibody
Product Specifications
Background
Voltage-dependent calcium channels are essential for the release of neurotransmitters. Cacna2d1 (calcium channel, voltage-dependent, alpha 2/delta subunit 1), also known as CACNA2, CCHL2A, MHS3 or CACNL2A, is a 1,091 amino acid single-pass type I membrane protein that contains one VWFA domain and one cache domain. Expressed in skeletal muscle, aorta tissues and in the central nervous system (CNS), Cacna2d1 functions as an alpha-2/delta subunit of voltage-dependent calcium channels and plays an important role in calcium current density, as well as in excitation-contraction coupling. The Cacna2d1 precursor is proteolytically processed to produce two functional subunits, designated alpha-2-1 and delta-1, which are disulfide-linked to one another.
Synonyms
Calcium channel L type DHPR alpha 2 subunit; CA2D1_HUMAN; CACN A2; CACNA2; CACNA2D1; CACNL2A; Calcium channel L type alpha 2 polypeptide; Calcium channel voltage dependent alpha 2/delta subunit 1; CCHL2A; Dihydropyridine receptor alpha 2 subunit; Dihydropyridine sensitive L type calcium channel alpha 2/delta subunit; Dihydropyridine sensitive L type calcium channel subunits alpha 2/delta; H_DJ0560O14.1; L type calcium channel subunit alpha 2; MHS 3; MHS3; Voltage dependent calcium channel subunit alpha 2/delta 1; Voltage gated calcium channel subunit alpha 2/delta 1; Voltage-dependent calcium channel subunit delta-1; Voltage-gated calcium channel subunit alpha-2/delta-1; WUGSC:H_DJ0560O14.1.
Cellular Locus
Cell membrane
Host
Rabbit
Immunogen
571-610/1103
Target
CACNA2
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human CACNA2/CACNA2D1
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Predicted Cross Reactivity
Human, Mouse, Rat, Dog, Cow, Pig, Horse
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