E3 ligase Ligand 7
E3 ligase Ligand 7 (Compound 6) is a ligand for E3 ligase. E3 ligase Ligand 7 can be utilized for the synthesis of PROTAC BET Degrader-12 (HY-158764) [1].
Product Specifications
CAS Number
[37630-54-9]
UNSPSC
12352005
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e3-ligase-ligand-7.html
Smiles
O=C(O)/C(C#N)=C/C1=CC=C2C=CC=CC2=C1
Molecular Formula
C14H9NO2
Molecular Weight
223.23
References & Citations
[1]Tin G, et al., Discovery of a DCAF11-dependent cyanoacrylamide-containing covalent degrader of BET-proteins. Bioorg Med Chem Lett. 2024 Jul 15;107:129779.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DCAF11
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