SLC25A12 Polyclonal Antibody

Calcium signaling in mitochondria is important in order for it to function in response to a variety of extracellular stimuli. Signaling begins with Ca (2+) entry in mitochondria via the Ca (2+) uniporter followed by Ca (2+) activation of three dehydrogenases in the mitochondrial matrix. ARALAR, the neuronal Ca (2+) -binding mitochondrial aspartate-glutamate carrier, has Ca (2+) binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS) . ARALAR is encoded by the SLC25A12 gene and is expressed in brain and skeletal muscle. ARALAR is required for the synthesis of brain aspartate and N-acetylaspartatemay and plays a role in myelin formation. It is also essential for the transmission of small Ca (2+) signals to mitochondria via an increase in mitochondrial NADH. In addition, ARALAR is implicated in conferring susceptibility to schizophrenia.

AGC1; Araceli hiperlarga; ARALAR; ARALAR1; Calcium binding mitochondrial carrier superfamily member; Calcium-binding mitochondrial carrier protein Aralar1; CMC1_HUMAN; Mitochondrial aspartate glutamate carrier 1; SLC25A12; Solute carrier family 25 member 12; solute carrier family 25, member 12.