Chlorahololide D

Chlorahololide D is a potent and selective Potassium Channel blocker with an IC50 value of 2.7 μM. Chlorahololide D is a nature product that could be isolated from the whole plant of Chloranthus holostegius[1].

Product Specifications

CAS Number

[943136-39-8]

UNSPSC

12352005

Target

Potassium Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/chlorahololide-d.html

Solubility

10 mM in DMSO

Smiles

COC(/C(C)=C1[C@]2([H])[C@@]34[C@](CC5=C2[C@]([C@@]6([H])[C@]5([H])C6)([C@H](C/1=O)O)C)([H])[C@]7([C@@]8([H])[C@]([C@](O)([C@]7([H])CC3=C(C(O4)=O)COC(C)=O)COC(/C(C)=C/C)=O)([H])C8)C)=O

Molecular Formula

C38H44O11

Molecular Weight

676.75

References & Citations

[1]Ping YS, et, al. Chlorahololides C–F: a new class of potent and selective potassium channel blockers from Chloranthus holostegius. Tetrahedron. 2008 Feb 25;64 (9) : 2027-34.