KALRN Polyclonal Antibody, AbBy Fluor™ 405 Conjugated

HAP1 (huntingtin-associated protein 1) binds to huntingtin (1) . Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington?s disease (HD) (2,3) . The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region (1) . HAP1 shows neuronal localization and moves with huntingtin in nerve fibers (4,5) . HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem (1) . Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons (6) . Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.

Duo; FLJ16443; HAPIP; Huntingtin associated protein interacting protein duo ; Huntingtin-associated protein-interacting protein; Kalirin isoform 2; Kalirin; KALRN ; KALRN_HUMAN ; Protein Duo; RhoGEF kinase; Serine/threonine kinase with Dbl and pleckstrin homology domains ; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain; TRAD.