ITM2C Polyclonal Antibody, Biotin Conjugated
Product Specifications
Background
Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
Synonyms
BRI3; BRICD2C; BRICHOS domain containing 2C; Cerebral protein 14; CT-BRI3; E25; E25C ; Integral membrane protein 2C; Integral membrane protein 3; Itm2c; ITM2C_HUMAN; ITM3 antibodyNPD018; Transmembrane protein BRI3.
Gene ID
81618
Swiss Prot
Q9NQX7
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Immunogen
3-88/267
Target
ITM2C
Clonality
Polyclonal
Isotype
IgG
Conjugation
Biotin
Source
KLH conjugated synthetic peptide derived from human ITM2C
Applications
WB, ELISA, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
81618
Predicted Cross Reactivity
Human, Mouse, Rat, Dog, Cow, Sheep, Pig, Horse
Curated Selection
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