Frizzled 9 Polyclonal Antibody
Product Specifications
Background
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Synonyms
FZD3; CD349; Frizzled-9; Fz-9; hFz9; FzE6; FZD9
Gene ID
8326
Swiss Prot
O00144
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human
Immunogen
185-270/591
Target
Frizzled 9
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human Frizzled 9/CD349
Applications
WB, ELISA, IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Specificity
This antibody may have slight cross reactivity with Frizzled 10.
Gene ID URL
8326
Predicted Cross Reactivity
Mouse, Rat, Dog
Available Sizes
Curated Selection
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