ENSA Polyclonal Antibody, RBITC Conjugated
Product Specifications
Background
Sulfonylureas are a class of drugs commonly used in the management of noninsulin-dependent diabetes mellitus. ENSA/ARPP-19, also known as ARPP-19e, is a 121 amino acid protein that localizes to the cytoplasm and belongs to the endosulfine family. ENSA/ARPP-19 is an endogenous regulator of the _-cell K (ATP) channels and reduces K (ATP) channel currents by inhibiting sulfonylurea from binding to the receptor thereby stimulating insulin secretion by pancreatic _ cells. It is suggested that ENSA/ARPP-19 expression is decreased in brains of both Alzheimer's disease (AD) and Down's syndrome patients. Widely expressed with high levels in skeletal muscle and brain and lower levels in pancreas, ENSA/ARPP-19 is phosphorylated by PKA and exists as eight alternatively spliced isoforms. ENSA/ARPP-19 is encoded by a gene located on human chromosome 1q21.3.
Synonyms
Alpha endosulfine; ARPP 19e; Endosulfine alpha; ENSA_HUMAN.
Cellular Locus
Cytoplasm
Host
Rabbit
Immunogen
51-121/121
Target
ENSA
Clonality
Polyclonal
Isotype
IgG
Conjugation
RBITC
Source
KLH conjugated synthetic peptide derived from human ENSA/ARPP-19
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
570nm/595nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Predicted Cross Reactivity
Human, Mouse, Rat, Dog, Cow, Horse, Rabbit
Curated Selection
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