DMPK Polyclonal Antibody

Myotonic dystrophy protein kinase is a multi-domain protein kinase found in muscle that is activated in response to G protein second messengers and proteolysis (1) . DMPK is implicated in myotonic muscular dystrophy (DM), an autosomal dominant-inherited disorder that predominately affects skeletal and cardiac muscle and causes defects in cardiac conduction (2,3) . DM arises through expansion of CTG repeats in the 3?-UTR of the DMPK gene (4) . Mutant DMPK transcripts with an extended region of CUG repeats are retained in the nucleus (5) . These transcripts also influence the expression of the DM locus-associated homeodomain protein (DMAHP) /SIX5, to mediate in part the DM phenotype (6) . Other substrates for DMPK include myogenin, L-type calcium channels, and Phospholemman (PLM) (1) .

Dystrophia myotonica protein kinase; DM 1; DM; DM kinase; DM protein kinase; DM-kinase; DM1; DM1 protein kinase; DM1PK; DMK; DMPK; DMPK_HUMAN; Dystrophia myotonica 1; Dystrophia myotonica protein kinase; MDPK; MT PK; MT-PK; Myotonic dystrophy associated protein kinase; Myotonic dystrophy protein kinase; Myotonin protein kinase A; Myotonin protein kinase; Myotonin-protein kinase; Thymopoietin homolog.