Senataxin Polyclonal Antibody, PE Conjugated

Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224) . Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850) . Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly (A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224) . Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity) . Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789) . In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744) . Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity) . May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256) . Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111) .