FISH Polyclonal Antibody, Biotin Conjugated

Fish, a potential Src substrate, is a broadly expressed adaptor protein containing five SH3 domains and a phox homology (PX) domain (1) . The Src family of protein tyrosine kinases act in signal transduction pathways (2-4) . Src kinases vary in expression but are strongly regulated in vivo; catalytic activity is repressed by interacting with the SH3 domain (5-7) . In Src-transformed fibroblasts and in normal cells treated with certain growth factors fish is tyrosine-phosphorylated (1) . Treatment of cells with cytochalasin D results in rapid tyrosine phosphorylation of fish, along with activation of Src (1) . Fish is likely to be involved in tyrosine kinase signaling and may have a role in cytoskeletal changes (1) .

Adapter protein TKS5; Five SH3 domain-containing protein; SH3 and PX domain-containing protein 2A; SH3 multiple domains protein 1; Sh3md1; Sh3pxd2a; SPD2A_HUMAN; TKs5; Tyrosine kinase substrate with five SH3 domains.