Aph-1b Polyclonal Antibody, AbBy Fluor™ 488 Conjugated
Product Specifications
Background
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein) . It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
Synonyms
PSFL; APH-1B; PRO1328; TAAV688; Gamma-secretase subunit APH-1B; Aph-1beta; Presenilin-stabilization factor-like; APH1B; UNQ688/PRO1328
Gene ID
83464
Swiss Prot
Q8WW43
Cellular Locus
Cell membrane
Host
Rabbit
Immunogen
51-150/257
Target
Aph-1b
Clonality
Polyclonal
Isotype
IgG
Conjugation
AbBy Fluor™ 488
Source
KLH conjugated synthetic peptide derived from human Aph-1b
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
499nm/519nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
83464
Predicted Cross Reactivity
Human, Mouse, Rat, Dog, Cow, Sheep, Pig
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